Pretargeted RIT using Antibody-Streptavidin Fusion Proteins
نویسندگان
چکیده
1 Department of Medicine, University of North Carolina, Chapel Hill, NC, USA; 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; 3 Department of Medicine, University of Washington, Seattle, WA, USA; 4 Department of Radiation Oncology, University of Washington, Seattle, WA, USA; 5 Department of Bioengineering, University of Washington, Seattle, WA, and 6 University Hospital of Lausanne, CH-1011 Lausanne, Switzerland. # These investigators contributed equally to this manuscript and are therefore assigned as co-first authors in alphabetical order.
منابع مشابه
Comparison of a tetravalent single-chain antibody-streptavidin fusion protein and an antibody-streptavidin chemical conjugate for pretargeted anti-CD20 radioimmunotherapy of B-cell lymphomas.
The efficacy of radioimmunotherapy (RIT) for patients with relapsed non-Hodgkin lymphoma (NHL) is limited by nonspecific delivery of radiation to normal tissues due to the long circulating half-life of radiolabeled anti-CD20 antibodies (Abs). Pretargeted RIT using a covalent conjugate of the 1F5 anti-CD20 Ab with streptavidin (SA) has been shown to augment the efficacy of RIT and decrease toxic...
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Running title: CD38 pretargeted RIT for plasma cell malignancies Disclosure of COI: The authors have no conflicts of interest to disclose. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. ABSTRACT The vast majority of patients with plasma cell neoplasms die of progressive disease despite high response rates to novel agents. Malignant plasma c...
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تاریخ انتشار 2011